Caspase 6 (CASP6) ELISA Kit


Human caspase 6 ELISA kit is designed for detecting in vitro quantitative concentrations of caspase-6 (CASP-6, CASP6) in human tissue homogenates, serum, cell lysates, other biological fluids, cell culture supernatant and plasma. This assay has a minimum sensitivity limit of < 0.069 ng/ml.


Caspase 6 (CASP6 or Mch2) is one of the main executioner caspases that is important for the cellular apoptotic process. This protein is found to be processed by caspases-7, -8 and -10, where it is thought to function predominately as a downstream enzyme of the caspase cascade. The following caspase 6 ELISA kit is ideal for measuring various diagnostic applications. There is evidence that caspase 6 is able to undergo self-processing without the requirement of other caspase family member. Caspase 3 and 6 are the main active caspases found in apoptotic cells and both of these are activated as a result of different apoptosis inducing stimuli. Also, caspase 6 has the ability to cleave nuclear mitotic apparatus protein and mediate the fragmentation or shrinkage of the nuclei. Essentially caspase 6 can interact with caspase 8, one of its main target includes the membrane associated protein lamin A and also the cleavage of this protein is found to result in cell membrane bleebing, malfunction and leading to eventual cell death. This caspase 6 ELISA kit offers a minimum sensitivity detection limit of 0.069 ng/ml and can be used to measure many different types of samples such as:  cell lysates, cell culture supernatant, serum, cell culture supernatant, plasma and many biological fluids.


Minimum detection limits of a caspase-6 (CASP6, CASP-6) using current human caspase 6 ELISA kit was 0.069 ng/ml. The dynamic range for this assay is 0.156 – 10.0 ng/ml.


  1. Activation and regulation of caspase-6 and its role in neurodegenerative diseases. Annu Rev Pharmacol Toxicol. (2015) 55: 553-72. Wang X.J., et al.
  2. Modulating caspase activity: beyond the active site. Curr Opin Struct Biol. (2013) 23 (6): 812-9. Review. Murray J. and Renslo A.R.
  3. Caspase-6 as a novel early target in the treatment of Alzheimer’s disease. Eur J Neurosci. (2013) 37 (12): 2005-18. Review. LeBlanc A.C.
  4. Vasculogenic mimicry: Possible role of effector caspase-3, caspase-6 and caspase-7. Ann Anat. (2016) 204: 114-7. Review. Linder M. and Tschernig T.
  5. The role of apoptotic pathways in Alzheimer’s disease neurodegeneration and cell death. Curr Alzheimer Res. (2005) 2 (4): 389-402. Review. LeBlanc A.C.


  • Full Name: Caspase 6 (CASP6) ELISA Kit
  • Reactivity: Human
  • Sample Type: Serum, Cell Culture Supernatant, Tissue Homogenates, Plasma, Other Biological Fluids, Cell Lysates
  • Sensitivity: < 0.069 ng/ml



Your secretory IgA ELISA gave good results and I was also really impressed with how quickly we received it.

L. Johnston
PhD Student / University of Glasgow

It is refreshing to know that you have a technical team that is very knowledgeable. I have already recommended your company to other researchers in our department.

Dr. P. Anderson
Lecturer / University College London (UCL)

I am a first time user and found that your instruction manual was very easy to follow. The insulin ELISA assay performed well and I was happy with the results that were generated.

J. Thomas
Senior Technician / Addenbrooke’s Hospital

I carried out a pilot study comparing the performance of many ELISA assay's from different suppliers and found your kits to be one of the better performers. We observed good linearity and tight replicates.

Dr. C. Davies
Lead Scientists / AstraZeneca

You are my first point of contact when I am looking to purchase ELISA. You have such an easy and simple system, yet it is very effective.

A. Shaw
Purchasing / University of Oxford