- Created on the 5 April, 2017.
Human caspase 6 ELISA kit is designed for detecting in vitro quantitative concentrations of caspase-6 (CASP6) in human tissue homogenates, serum, cell lysates, other biological fluids, cell culture supernatant and plasma. This assay has a minimum sensitivity limit of < 0.069 ng/ml.
Caspase 6 (CASP6 or Mch2) is one of the main executioner caspases that is important for the cellular apoptotic process. This protein is found to be processed by caspases-7, -8 and -10, where it is thought to function predominately as a downstream enzyme of the caspase cascade. There is evidence that caspase 6 is able to undergo self-processing without the requirement of other caspase family member. Caspase 3 and 6 are the main active caspases found in apoptotic cells and both of these are activated as a result of different apoptosis inducing stimuli. Also, caspase 6 has the ability to cleave nuclear mitotic apparatus protein and mediate the fragmentation or shrinkage of the nuclei. Essentially caspase 6 can interact with caspase 8, one of its main target includes the membrane associated protein lamin A and also the cleavage of this protein is found to result in cell membrane bleebing, malfunction and leading to eventual cell death. The following caspase 6 ELISA kit is ideal for measuring various diagnostic applications.
Minimum detection limits of a caspase-6 (CASP6) using current human caspase 6 ELISA kit was 0.069 ng/ml. The dynamic range for this assay is 0.156 – 10.0 ng/ml.
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- Full Name: Caspase 6 (CASP6) ELISA Kit
- Reactivity: Human
- Sample Type: Serum, Cell Culture Supernatant, Tissue Homogenates, Plasma, Other Biological Fluids, Cell Lysates
- Sensitivity: < 0.069 ng/ml