- Created on the 16 May, 2017.
Troponin I is an important cardiac and skeletal muscle protein and has been a vital tool for diagnosing heart attack. It belongs to the troponin protein complex and has the ability to bind actin in the thin myofilaments in order to hold the actin-tropomyosin complex together. Cardiac troponin I, which is often referred to as cTn-I, consists of 209 amino acids with a molecular weight of 23.9 kDa and it is present within cardiac muscle tissue as a single isoform. cTnI is found to differ from other troponins family members because of its 26 amino acids extension in the N-terminal. Multiple reaction which are able to monitor human cTnI has identified at least 14 phosphorylation sites and also found that the phosphorylation pattern in these sites can changed in response to disease. Troponin I, however, is not only specific for myocardial damage secondary to infarction but has been known to be elevated in heart failure, chronic renal failure, chronic renal failure and subarachnoid haemorrhage.
Human cardiac troponin I ELISA kit is a protocol for measuring in vitro quantitative concentrations of cardiac troponin I (cTn-I) in human cell culture supernatant, plasma, serum, cell lysates and other biological fluids. This assay has a minimum sensitivity limit of 2.54 ng/L.
The minimum detection sensitivity level of human cTn-I using this human cardiac troponin I ELISA kit was 2.54 ng/L. The dynamic assay range for this kit is 5.0 – 1,500.0 ng/L.
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- Full Name: Cardiac Troponin I (cTn-I) ELISA Kit
- Reactivity: Human
- Sample Type: Serum, Other Biological Fluids, Plasma, Cell Culture Supernatant, Cell Lysates
- Sensitivity: 2.54 ng/L