- Created on the 16 May, 2017.
Human BNP ELISA kit is designed for analysing in vitro quantitative levels of brain natriuretic peptide (BNP, natriuretic-peptide B, ventricular natriuretic-peptide, B-type natriuretic-peptide) in human serum, plasma, other biological fluids, cell culture supernatant and cell lysates. This assay has a minimum sensitivity limit of 2.56 ng/L.
Brain natriuretic peptide which can also be called B-type natriuretic peptide (BNP) or natriuretic peptide B or ventricular natriuretic peptide, it is secreted in response to excessive stretching of the heart muscle cells by the ventricles. BNP is secreted attached to a prohormone (NT-proBNP), this is a 76 amino acid N-terminal fragment and it is biologically inactive. Once it is released BNP will bind and activate the atrial natriuretic factor receptors (NPRA) and the physiological actions include decreasing central venous pressure and systemic vascular resistance, in addition to an increase in natriuresis. The overall action of both BNP leads to a decrease in cardiac output, which ultimately results in a reduction in blood volume that follows diuresis and natriuresis. Both BNP and NT-proBNP have been useful in screening and prognosis of heart failure. The levels of both of these is typically elevated in patients having left ventricular dysfunction. Also, recombinant BNP and nesiritide have been vital in treating decompensate heart failure. BNP ELISA kit is useful for analysing various diagnostic applications.
The minimum detection sensitivity level of brain natriuretic peptide (B-type natriuretic peptide) using current human BNP ELISA kit was 2.56 ng/mL. The dynamic range for this assay is 5.0 – 2,000.0 ng/L.
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- Full Name: Brain Natriuretic Peptide (BNP) ELISA Kit
- Reactivity: Human
- Sample Type: Serum, Cell Culture Supernatant, Plasma, Cell Lysates, Other Biological Fluids
- Sensitivity: 2.56 ng/L