GET A QUOTE

Bordetella Pertussis Toxin IgG ELISA Kit

  • Created on the 12 July, 2017.

BACKGROUND

Pertussis toxin (PT) is a hexamer protein which is 105 kDa and it forms a typical AB5 architecture. PT is found to interfere with early production of chemokine and inhibit neutrophil chemotaxis by directly affecting the innate immune response (it inhibits the recruitment of both neutrophils and macrophages). It is vital in the colonisation of respiratory tract and in establishing infection. Recent research is indicating a possible therapeutic role in treating a number of human ailments.

INTENDED USE

Human Bordetella pertussis toxin-IgG ELISA kit can be used for analysing in-vitro quantitative amounts of human IgG antibodies against Bordetella pertussis using samples of serum and plasma. This assay has a minimum analytical sensitivity limit of 0.43 IU/ml.

SENSITIVITY

The minimum detection sensitivity level of human Bordetella pertussis toxin IgG using this human Bordetella pertussis toxin-IgG ELISA kit was 0.43 IU/ml. The dynamic assay range for this kit is 25.0 – 150.0 IU/ml.

REFERENCES

  1. Modelling anti-pertussis toxin IgG antibody decay following primary and preschool vaccination with an acellular pertussis vaccine in UK subjects using a modified oral fluid assay. J Med Microbiol. (2013) 62 (Pt 9): 1281-9. Fry N.K., et al.
  2. Comparative study of different sources of pertussis toxin (PT) as coating antigens in IgG anti-PT enzyme-linked immunosorbent assays. Clin Vaccine Immunol. (2012) 19 (1): 64-72. Kapasi A., et al.
  3. Age-specific long-term course of IgG antibodies to pertussis toxin after symptomatic infection with Bordetella pertussis. Epidemiol Infect. (2005) 133 (4): 737-48. Versteegh F.G., et al.
  4. Pertussis toxin improves immune responses to a combined pneumococcal antigen and leads to enhanced protection against Streptococcus pneumoniae. Clin Vaccine Immunol. (2014) 21 (7): 972-81. Salcedo-Rivillas C., et al.
  5. Differences in avidity of IgG antibodies to pertussis toxin after acellular pertussis booster vaccination and natural infection. Vaccine. (2012) 30 (48): 6897-902. Barkoff A.M., et al.

ADDITIONAL INFORMATION

  • Full Name: Bordetella Pertussis Toxin IgG ELISA Kit
  • Reactivity: Human
  • Sample Type: Serum, Plasma
  • Sensitivity: 0.43 IU/ml

OTHER RELATED ELISA KITS

TESTIMONIALS arrow icon

Your secretory IgA ELISA kit gave good results and I was also really impressed with how quickly we received it.

L. Johnston
PhD Student / University of Glasgow

It is refreshing to know that you have a technical team that is very knowledgeable. I have already recommended your company to other researchers in our department.

Dr. P. Anderson
Lecturer / University College London (UCL)

I am a first time user and found that your instruction manual was very easy to follow. The insulin ELISA kit performed well and I was happy with the results that were generated.

J. Thomas
Senior Technician / Addenbrooke’s Hospital

I carried out a pilot study comparing the performance of many ELISA kits from different suppliers and found your kits to be one of the better performers. We observed good linearity and tight replicates.

Dr. C. Davies
Lead Scientists / AstraZeneca

You are my first point of contact when I am looking to purchase ELISA kits. You have such an easy and simple system, yet it is very effective.

A. Shaw
Purchasing / University of Oxford