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Beta 2 Microglobulin (B2MG) ELISA Kit

  • Created on the 22 March, 2017.

BACKGROUND

Beta 2 microglobulin (B2MG) is a 11 kDA protein that was originally identified as a small serum protein, this small size helps B2MG to pass through the glomerular membrane and it is also often completely reabsorbed in the proximal tubules. It is able to form the subunit of the MHC class I molecule and also be associated with many outer membrane of a number of cells which includes lymphocytes. It is usually is present in the subunit of class I major histocompatibility complex (MHC I) which can be found expressed on all nucleated cell except red blood cells. B2MG is also linked with MHC I-like molecules for example CD1 and Qa.

Generally it is present in minute amounts but tends to increase its expression or even adapt to the fibrillary configuration depending on certain pathological states. Often B2MG is present at low levels in the serum or urine of normal people, however these concentrations are much higher in patients having kidney transplants, renal diseases and various other infectious or inflammatory conditions. This immunoassay is an ideal tool for analysing the function and regulation of this protein.

INTENDED USE

Human beta 2 microglobulin ELISA kit can be used for determining in vitro quantitative amounts of beta(2)-microglobulin (B2MG) in human serum, cell culture supernatant and various other biological samples. This assay has a minimum detection limit of < 0.2 μg/mL.

SENSITIVITY

The minimum detection sensitivity level human beta 2 microglobulin using this human human beta 2 microglobulin ELISA kit was 3.0 μg/mL. The dynamic assay range for this kit is 0.75 – 12.0 μg/mL.

REFERENCES

  1. Beta2-microglobulin: emerging as a promising cancer therapeutic target. Drug Discov Today. (2009) 14 (1-2): 25-30. Review. Shi C., et al.
  2. Solution structure of beta(2)-microglobulin and insights into fibrillogenesis. Biochim Biophys Acta. (2005) 1753 (1): 76-84. Review. Esposito G., et al.
  3. Role of beta(2)-microglobulin in the immune response in renal osteodystrophy. Semin Dial. (2001) 14 (2): 113-6. Review. Balint E.
  4. Understanding the complex mechanisms of β2-microglobulin amyloid assembly. FEBS J. (2011) 278 (20): 3868-83. Review. Eichner T. and Radford S.E.
  5. β2-Microglobulin-mediated signaling as a target for cancer therapy. Anticancer Agents Med Chem. (2014) 14 (3): 343-52. Review. Nomura T., et al.

ADDITIONAL INFORMATION

  • Full Name: Beta 2 Microglobulin (B2MG) ELISA Kit
  • Reactivity: Human
  • Sample Type: Serum, Other Biological Samples, Cell Culture Supernatant
  • Sensitivity: < 0.2 μg/mL

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