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Bactericidal/Permeability-Increasing protein (BPI) ELISA Kit

  • Created on the 26 May, 2017.

BACKGROUND

Bactericidal/permeability-increasing protein (BPI) is a 456 residue cationic protein which is approx. 50kDa in size, produced only by precursors of polymorphonuclear leukocytes and forms part of the innate immune system. BPI has potent killing activity against gram-negative bacteria and is often referred to as an endogenous antibiotic protein. It has the ability to binds to compounds which are known as lipopolysaccharides, these are potent activators of the immune system. There is evidence that a certain concentration of BPI can prevent this activation process.

INTENDED USE

Human BPI ELISA kit can be used for measuring in vitro quantitative concentrations of IgG autoantibodies to bactericidal/permeability-increasing protein (BPI) in human seruma and plasma. This assay has a minimum analytical sensitivity limit of 0.5 U/ml.

SENSITIVITY

The minimum detection sensitivity level of human bactericidal/permeability-increasing protein using this human BPI ELISA kit was 0.5 U/ml. The dynamic assay range for this kit is 6.3 – 100.0 U/ml.

REFERENCES

  1. The bactericidal/permeability-increasing protein (BPI) in infection and inflammatory disease. Clin Chim Acta. (2007) 384 (1-2): 12-23. Review. Schultz H. and Weiss J.P.
  2. Meet the relatives: a family of BPI- and LBP-related proteins. Trends Immunol. (2004) 25 (2): 53-5. Review. Bingle C.D. and Craven C.J.
  3. Prospects for use of recombinant BPI in the treatment of gram-negative bacterial infections. Infect Agents Dis. (1995) 4 (2): 102-9. Review. Elsbach P. and Weiss J.
  4. Antimicrobial peptides and colitis. Curr Pharm Des. (2013) 19 (1): 40-7. Review. Ho S., et al.
  5. Expression of BPI (bactericidal/permeability-increasing protein) in human mucosal epithelia. Biochem Soc Trans. (2003) 31 (Pt 4): 795-800. Review. Levy O., et al.
  6. Antimicrobial peptides: the ancient arm of the human immune system. Virulence. (2010) 1 (5): 440-64. Review. Wiesner J. and Vilcinskas A.

ADDITIONAL INFORMATION

  • Full Name: Bactericidal/Permeability-Increasing protein(BPI) ELISA Kit
  • Reactivity: Human
  • Sample Type: Serum, Plasma
  • Sensitivity: 0.5 U/ml

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