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Atrial Natriuretic Peptide (ANP) ELISA Kit

  • Created on the 16 May, 2017.

BACKGROUND

Atrial natriuretic peptide (ANP) can also be referred to as atrial natriuretic hormone (ANH), atrial natriuretic factor (ANF), atriopeptin, cardionatrine and cardiodilatin. It is a 28 amino acid polypeptide hormone which is secreted by heart muscle cells, a powerful vasodilator. ANP is responsible for reducing the blood pressure by regulating homeostatic control of the body water, fat, sodium and potassium levels. It is often released by muscles cells in the atria of the heart in response to high blood volume. It can be secreted in response to raised sodium concentration, stretching of the atrial wall, endothelin, increased sympathetic stimulation of β-adrenoceptors and exercise. ANP is able to bind to a specific set of receptors which are called ANP receptors, this results in reducing blood volume, systemic blood pressure and a reduction in cardiac output. Generally, the function of ANP is to counter the increase in the volume and pressure of blood that is caused via the renin-angiotensin system. ANP and many of its related peptides are important biomarkers for many cardiovascular diseases such as coronary artery disease, stroke, heart failure and myocardial infarction. Also, recombinant human ANP has been approved in Japan to be used in order to treat patients experiencing heart failure.

INTENDED USE

Human ANP ELISA kit is a procedure intended for determining in vitro quantitative amounts of atrial natriuretic peptide (ANF, ANH, ANP) in human serum, cell lysates, plasma, other biological fluids and cell culture supernatant. This assay has a minimum sensitivity limit of 2.52 ug/ml.

SENSITIVITY

The minimum detection sensitivity level of human ANP (ANH, ANF) using this human atrial natriuretic peptide ELISA kit was 2.52 ug/ml. The dynamic assay range for this kit is 5.0 – 1,000.0 ug/ml.

REFERENCES

  1. Human atrial natriuretic peptide treatment for acute heart failure: a systematic review of efficacy and mortality. Can J Cardiol. (2012) 28 (1): 102-9. Review. Kobayashi D., et al.
  2. Novel natriuretic peptides: new compounds and new approaches. Curr Heart Fail Rep. (2011) 8 (1): 22-7. Review. Vogel M.W and Chen H.H.
  3. Biomarkers and heart disease. Eur Rev Med Pharmacol Sci. (2014) 18 (19): 2927-35. Review. Sun R.R., et al.
  4. Roles of atrial natriuretic peptide and its therapeutic use. J Cardiol. (2010) 56 (3): 262-70. Review. Saito Y.
  5. Natriuretic peptides in the pathophysiology of congestive heart failure. Curr Cardiol Rep. (2000) 2 (3): 198-205. Review. Chen H.H. and Burnett J.C.

ADDITIONAL INFORMATION

  • Full Name: Atrial Natriuretic Peptide (ANP) ELISA Kit
  • Reactivity: Human
  • Sample Type: Cell Lysates, Plasma, Cell Culture Supernatant, Serum, Other Biological Fluids
  • Sensitivity: 2.52 ug/ml

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