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Ascaris Lumbricoides IgG ELISA Kit

  • Created on the 13 July, 2017.

BACKGROUND

Ascaris lumbricoides is one of the most common parasitic worm in humans which has the capacity of growing up to lengths of 35 cm, it is often referred to has a “giant roundworm”. This organism can lead to the disease ascariasis, which is a type of helminthiaisis (a neglected tropical disease group). Ascaris lumbricoides is able to infect humans after an ingested fertilised egg becomes a larval worm, this is able penetrate the walls of the duodenum and then enter into the blood stream. From here it is able to enter the liver, heart and the pulmonary circulatory system before breadking free into the alveoli where it can grow and molt. One of its key characteristics is its large size (approx. 2-6 mm diameter and 15-50 cm long). There are an estimated 1 billion people in the world that are infected, it is most common in America, East Asia, China and sub-Saharan Africa. The infection with this parasite is usually is places where the sanitation is poor and in many cases raw human feces are being used as fertilisers. The prevention of any fecal-borne disease requires an education in hygienic cultures/habits, in addition to effective fecal treatment systems.

INTENDED USE

Human ascaris lumbricoides-IgG ELISA kit is designed to determine in-vitro quantitative levels of human IgG class antibodies to ascaris lumbricoides using serum or plasma samples. This assay has a minimum analytical sensitivity limit to diagn. > 95%.

SENSITIVITY

The minimum detection sensitivity level of human ascaris lumbricoides IgG using this human ascaris lumbricoides-IgG ELISA kit was to diagn. > 95%. The dynamic assay range for this kit is to a cut-off point.

REFERENCES

  1. Evaluation of IgG4 response in ascariasis by ELISA for serodiagnosis. Trop Med Int Health. (1996) 1 (5): 633-9. Chatterjee B.P., et al.
  2. Antibody responses to Ascaris-derived proteins and glycolipids: the role of phosphorylcholine. Parasite Immunol. (2006) 28 (8): 363-71. van Riet E., et al.
  3. The strength of the antibody response to the nematode Ascaris lumbricoides inversely correlates with levels of B-Cell Activating Factor (BAFF). BMC Immunol. (2014) 15: 22. Bornacelly A., et al.
  4. An investigation of the antigens of Ascaris lumbricoides using a radioimmunoassay and sera of naturally infected humans. Int Arch Allergy Appl Immunol. (1980) 61 (2): 213-9. O’Donnell I.J. and Mitchell G.F.
  5. Bronchial challenge of tropical asthmatics with Ascaris lumbricoides. J Investig Allergol Clin Immunol. (1992) 2 (2): 97-105. Lynch N.R., et al.

ADDITIONAL INFORMATION

  • Full Name: Ascaris Lumbricoides IgG ELISA Kit
  • Reactivity: Human
  • Sample Type: Plasma, Serum
  • Sensitivity: diagn. > 95%

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