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Anti-TSH Receptor Antibodies (TRAb) ELISA Kit

  • Created on the 2 February, 2017.

BACKGROUND

TSH receptor auotoantibodies (TRAb) are found to be predominantly located on the surfaces of thyroid epithelial cells, these are essentially autoantibodies that are directed against TSH receptors. They are particularly useful in helping to distinguish between Graves’ disease and postpartum thyroiditis. In many cases they can also be used to determine the likely risk of neonatal/foetal thyrotoxicosis. During pregnancy TRAb are able cross the placenta and in many instances affect the foetal thyroid. In these cases a positive test for TRAb can be used to alert the obstetrician of potential risks associated to the baby during the neonatal period, such as thyroid dysfunction in the offspring.

INTENDED USE

This anti-TSH receptor (TRAb) ELISA kit is a reliable quantitative procedure for measuring TSH (thyrotropin) receptor autoantibodies (TRAb) in human serum. The minimum sensitivity limit of this assay is 0.55 U/L.

SENSITIVITY

The minimum sensitivity detection limit of anti-TSH (thyrotropin) receptor autoantibodies using this anti-TSH receptor ELISA kit is 0.55 U/L. The dynamic assay range for this kit is 1.0 – 40.0 U/L (WHO).

REFERENCES

  1. Autoimmune response to the thyroid in humans: thyroid peroxidase–the common autoantigenic denominator. Int. Rev. Immunol. (2000). 19 (6): 587–618. McLachlan SM, Rapoport B.
  2. Anti-TSH receptor antibodies in clinical practice. Endocrinology and metabolism clinics of North America. (2000) 29 (2): 339–55. Orgiazzi, J.
  3. The human anti-thyroid peroxidase autoantibody repertoire in Graves’ and Hashimoto’s autoimmune thyroid diseases. Immunogenetics. (2002) 54 (3): 141–57. Chardès T, et al.

ADDITIONAL INFORMATION

  • Full Name: Anti-TSH Receptor Antibodies (TRAb) ELISA Kit
  • Reactivity: Human
  • Sample Type: Serum
  • Sensitivity: 0.55 U/L

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