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Anti-Mullerian Hormone (AMH) Gen II ELISA Kit

  • Created on the 21 February, 2017.

BACKGROUND

Anti-mullerian hormone (AMH) is a dimeric protein glycoprotein which has a molecular mass of 140 kDa. Structurally it is related to activing and inhibin and it is a member of the TGF-beta family. AMH is responsible for Mullerian duct regression during embryonic development. In females small amounts are secreted by the granulosa cells of the ovarian follicles after birth until menopause, after this it is undetectable. In males it is secreted by sertoli cells in the testes until puberty and after this it decreases slowly to residual post puberty values.

Measuring AMH level have been a helpful marker to assess ovarian egg reserve and therefore fertility. It can be measured any time throughout the menstrual cycle since it is known to be stable throughout the cycle. AMH levels are naturally found to be lower in older women (usually over the age of 40) and higher in women with that have polycystic ovary syndrome (PCOS) or polycystic ovary syndrome (PCOS). Women with higher AMH values will also have a better chance a good response to ovarian stimulation for IVF, since they have more eggs retrieved and generally the more eggs presents leads to a higher success rate with IVF.

For accurate assessment, it is recommended to perform AMH assays alongside an antral follicle count – AFC (number of small follicles within both ovaries). In humans, the number of cells that are present in the follicular reserve is used to predict timing of menopause.

INTENDED USE

Anti-mullerian hormone ELISA kit is a reliable quantitative procedure for measuring anti-mullerian hormone (AMH) in human serum and lithium plasma samples. This assay has a minimum sensitivity detection limit of 0.08 ng/ml.

SENSITIVITY

The minimum sensitivity detection limit of AMH using this human anti-mullerian hormone ELISA kit was approximately 0.08 ng/ml. The dynamic assay range for this kit is 0.14 – 22.0 ng/ml.

REFERENCES

  1. The role of anti-Müllerian hormone in female fertility and infertility – an overview. Acta Obstet Gynecol Scand. (2012) 91 (11): 1252-60. Review. Grynnerup A.G., et al.
  2. Assessing ovarian response: antral follicle count versus anti-Müllerian hormone. Reprod Biomed Online. (2015) 31 (4): 486-96. Review. Fleming R., et al.
  3. The role of anti-Müllerian hormone in the pathogenesis and pathophysiological characteristics of polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. (2016) 199: 82-7. Review. Qi X., et al.
  4. Anti-Müllerian hormone (AMH) and its significance in women’s fertility. MLO Med Lab Obs. (2014) 46 (12): 22, 24. Faye S.

ADDITIONAL INFORMATION

  • Full Name: Anti-Mullerian Hormone (AMH) Gen II ELISA Kit
  • Reactivity: Human
  • Sample Type: Serum
  • Sensitivity: 0.05 ng/ml

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