- Created on the 31 May, 2017.
Anti-centromere antibodies (which can be also called ACAs or anti-centromere) are essential autoantibodies which are highly specific to kinetochore and centromere functions. They are usually found in limited systemic scleroderma (previously known as CREST syndrome) and sometimes in the diffuse form of scleroderma. However, these autoantibodies are quite rarely found in other rheumatic diseases or even in healthy individuals. The detection of autoantibodies which are directed against centromere protein B has become very important for the diagnostic and prognostic of progressive systemic scleroderma (PSS). Centromere protein B is a DNA-associated protein and together with other proteins, is vital in the formation of kinetochores. It is an essential target antigen for over 95% of patients that have Raynaud’s phenomenon and scleroderma. Since majority of autoantibodies against centromere proteins are present many year before the disease appears, this makes the detection of anti-centromere B a significant indicator for the onset of scleroderma.
Human anti-centromere B ELISA kit is designed for determining in vitro quantitative concentrations of IgG autoantibodies against centromere B in human serum and plasma. This assay has a minimum analytical sensitivity limit of 1.0 U/ml.
The minimum detection sensitivity level of human centromere B antibody using this human anti-centromere B ELISA kit was 1.0 U/ml. The dynamic assay range for this kit is 10.0 – 300.0 U/ml.
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- Full Name: Anti-Centromere ELISA Kit
- Reactivity: Human
- Sample Type: Serum, Plasma
- Sensitivity: 1.0 U/ml