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Anti-CCP ELISA Kit

  • Created on the 31 May, 2017.

BACKGROUND

Rheumatoid arthritis (RA) is a common chronic systemic autoimmune disease which can lead to significant clinical symptom such as inflammation of the joints which can result in the gradual damage and loss of their function. There are many treatments that can be used in order to minimise RA complications, however, this all depends on making an early and accurate diagnosis. Rheumatoid factor (RF) is the most common autoantibody test which has been used to diagnosis of RA and also distinguish it from many other inflammatory processes and types of arthritis. One drawback for the RF antibodies is that they are sensitive but not very specific markers, whereas CCP (cyclic citrullinated peptides) provide a much more specific for diagnosis of RA and can be detected in a very early asymptomatic stage.

Anti-CCP autoantibodies are found to be present in approx. 70% of patients having rheumatoid arthritis and it is thought to exist in a patient for many years before they develop any clinical rheumatoid arthritis symptoms. This means that a positive anti-CCP test can help to deliver a prognosis since many patients with positive anti-CCP results experience severe rheumatoid arthritis symptoms. This CCP test can also be useful in differentiating the collagen pathologies with concomitant arthritis from the RA and in providing an important prognostic value in monitoring articular radiologically detectable damage.

INTENDED USE

Human anti-CCP ELISA kit is designed for measuring in vitro quantitative levels of IgG class of autoantibodies against cyclic citrullinated peptides (CCP) in human plasma and serum. This assay has a minimum analytical sensitivity limit of 1.0 U/ml.

SENSITIVITY

The minimum detection sensitivity level of human cyclic citrullinated peptides (CCP) using this human anti-CCP ELISA kit was 1.0 U/ml. The dynamic assay range for this kit is 20.0 – 1,000.0 U/ml.

REFERENCES

  1. Diagnosing early-onset rheumatoid arthritis: the role of anti-CCP antibodies. Am Clin Lab. (2002) 21 (7): 34-6. Review. Vasishta A.
  2. Rheumatoid factor and anti-CCP autoantibodies in rheumatoid arthritis: a review. Clin Lab Sci. (2008) 21 (1): 15-8. Review. Lee A.N., et al.
  3. Antibodies against cyclic citrullinated peptides in infectious diseases–a systematic review. Clin Rheumatol. (2010) 29 (12): 1345-51. Review. Lima I. and Santiago M.
  4. Anti-citrullinated protein antibodies and their clinical utility in rheumatoid arthritis. Int J Rheum Dis. (2013) 16 (4): 379-86. Review. Farid S.Sh., et al.
  5. Anti-CCP Antibody, a Marker for the Early Detection of Rheumatoid Arthritis. Ann N Y Acad Sci. (2008) 1143: 268-85. Review. van Venrooij W.J., et al.

ADDITIONAL INFORMATION

  • Full Name: Anti-CCP ELISA Kit
  • Reactivity: Human
  • Sample Type: Plasma, Serum
  • Sensitivity: 1.0 U/ml

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