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Angiopoietin-Like 3 ELISA Kit (Mouse)

  • Created on the 28 October, 2017.

BACKGROUND

Angiopoietin-like 3 (ANGPTL3) is a protein that belongs to the angiopoietin-like family of secreted factors which is expressed mainly in the liver. It contains the standard characteristic structure that can be found in angiopoietins, a C-terminal fibrinogen (FBN)-like domain, N-terminal coiled-coil domain and a signal peptide. Some of the functions of ANGPTL3 include acting as a dual inhibitor of endothelial lipase (EL) and lipoprotein lipase (LPL), in order to increase the levels of HDL cholesterol and plasma triglyceride in rodents. It has been found to play a major role in promoting the uptake of circulating triglycerides into white adipose tissue during the fed state.

INTENDED USE

Mouse ANGPTL3 ELISA kit is designed for analysing quantitative amounts of angiopoietin-like 3 (ANGPTL3) in mouse serum, cell culture media and plasma samples. This assay has a minimum sensitivity detection limit of 0.04 ng/ml.

SENSITIVITY

The minimum sensitivity detection limit of angiopoietin-like 3 (ANGPTL3) using this mouse ANGPTL3 ELISA kit was approximately 0.04 ng/ml. The dynamic assay range for this kit is 0.31 – 20.0 ng/ml.

REFERENCES

  1.  Genetics and regulation of angiopoietin-like proteins 3 and 4. Curr Opin Lipidol. (2006) 17 (2): 152-6. Review. Li C.
  2.  Angptl3 regulates lipid metabolism in mice. Nat Genet. (2002) 30 (2): 151-7. Koishi R., et al.
  3. Identification of a mammalian angiopoietin-related protein expressed specifically in liver. Genomics. (1999) 62 (3): 477-82. Conklin D., et al.
  4. Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes. J Biol Chem. (2013) 288 (37): 26410-8. Essalmani R., et al.
  5. Different relationship between ANGPTL3 and HDL components in female non-diabetic subjects and type-2 diabetic patients. Cardiovasc Diabetol. (2016) 15 (1): 132. Zhao D., et al.

ADDITIONAL INFORMATION

  • Full Name: Angiopoietin-Like 3 ELISA Kit (Mouse)
  • Reactivity: Mouse
  • Sample Type: Plasma, Serum, Cell Culture Media
  • Sensitivity: 0.04 ng/ml

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