GET A QUOTE

Amyloid Beta (1-40) ELISA Kit (Rat/Mouse)

  • Created on the 28 October, 2017.

BACKGROUND

Amyloid beta (which is commonly referred to as Aβ or Abeta) denotes peptides that are between 36-43 amino acids in length and are responsible in Alzheimer’s disease, since one of the main components (i.e. amyloid plaques) has been identified in the brains of Alzheimer patients. Aβ molecules can exist in many forms by aggregating to form flexible soluble oligomers. There have been several potential activities which have been identified for amyloid beta for example protection against oxidative stress, anti-microbial activity, activation of kinase enzymes, functioning as a transcription factor and regulation of cholesterol transport. Senile plaques have been discovered to contain both Aβ40 and Aβ42, whilst the vascular amyloid is identified to contain mainly the shorter Aβ40. At present, ELISA assays and biomarkers have been important in detecting the concentrations of amyloid beta in order to identify Alzheimer’s disease in its early stages.

INTENDED USE

Rat/mouse amyloid beta (1-40) ELISA kit is designed for measuring quantitative levels of amyloid beta (Aβ, Abeta)(1-40) in rat or mouse serum, brain extract, cell culture supernatant and plasma samples. This assay has a minimum sensitivity detection limit of 0.28 pg/ml.

SENSITIVITY

The minimum sensitivity detection limit of amyloid beta (Aβ, Abeta) using this rat/mouse amyloid beta (1-40) ELISA kit was approximately 0.28 pg/ml. The dynamic assay range for this kit is 1.56 – 100.0 pg/ml.

REFERENCES

  1. Co-injection of Aβ1-40 and ApoE4 impaired spatial memory and hippocampal long-term potentiation in rats. Neurosci Lett. (2017) 648: 47-52. Wu M., et al.
  2. Personalized medicine in Alzheimer’s disease and depression. Contemp Clin Trials. (2013) 36 (2): 616-23. Review. Souslova T., et al.
  3. Glial markers and emotional memory in rats following acute cerebral radiofrequency exposures. Environ Sci Pollut Res Int. (2016) 23 (24): 25343-25355. Barthélémy A., et al.
  4. Nanotechnological strategies for nerve growth factor delivery: Therapeutic implications in Alzheimer’s disease. Pharmacol Res. (2017) 120: 68-87. Review. Faustino C., et al.
  5. Analysis of hippocampal gene expression profile of Alzheimer’s disease model rats using genome chip bioinformatics. Neural Regen Res. (2012) 7 (5): 332-40. Li Y., et al.

ADDITIONAL INFORMATION

  • Full Name: Amyloid Beta (1-40) ELISA Kit (Rat/Mouse)
  • Reactivity: Rat, Mouse
  • Sample Type: Brain Extract, Plasma, Cell Culture Supernatant, Serum
  • Sensitivity: 0.28 pg/ml

OTHER RELATED ELISA KITS

TESTIMONIALS arrow icon

Your secretory IgA ELISA kit gave good results and I was also really impressed with how quickly we received it.

L. Johnston
PhD Student / University of Glasgow

It is refreshing to know that you have a technical team that is very knowledgeable. I have already recommended your company to other researchers in our department.

Dr. P. Anderson
Lecturer / University College London (UCL)

I am a first time user and found that your instruction manual was very easy to follow. The insulin ELISA kit performed well and I was happy with the results that were generated.

J. Thomas
Senior Technician / Addenbrooke’s Hospital

I carried out a pilot study comparing the performance of many ELISA kits from different suppliers and found your kits to be one of the better performers. We observed good linearity and tight replicates.

Dr. C. Davies
Lead Scientists / AstraZeneca

You are my first point of contact when I am looking to purchase ELISA kits. You have such an easy and simple system, yet it is very effective.

A. Shaw
Purchasing / University of Oxford